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a) Protease-activated receptor 1 (PAR1) and the number of rears, b) Endothelin 1 <t>(ET1)</t> and the number of rears, c) PAR1 and the average displacement distance of each of the right and the left forepaw, d) ET1 and the average displacement distance of each of the right and the left forepaw, e) PAR1 and each of time to pick pasta (TPP) and time to finish eating (TTF), f) ET1 and each of TPP and TTF, g) PAR1 and number of times of adjustments of forepaws (NTAF), h) ET1 and NTAF. PAR1: protease-activated receptor 1; ET1: endothelin 1; TPP: time to pick up pasta; TTF: time to finish eating; NTAF: number of times of adjustment of forepaws. Spearman rho. Significant when Ρ < 0.05.
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a) Protease-activated receptor 1 (PAR1) and the number of rears, b) Endothelin 1 (ET1) and the number of rears, c) PAR1 and the average displacement distance of each of the right and the left forepaw, d) ET1 and the average displacement distance of each of the right and the left forepaw, e) PAR1 and each of time to pick pasta (TPP) and time to finish eating (TTF), f) ET1 and each of TPP and TTF, g) PAR1 and number of times of adjustments of forepaws (NTAF), h) ET1 and NTAF. PAR1: protease-activated receptor 1; ET1: endothelin 1; TPP: time to pick up pasta; TTF: time to finish eating; NTAF: number of times of adjustment of forepaws. Spearman rho. Significant when Ρ < 0.05.

Journal: Cureus

Article Title: Dabigatran Combined With Benztropine Ameliorates Cobalt Chloride-Induced Parkinsonism in Rats, Restores Protease-Activated Receptor 1 (PAR1), and Mitigates Oxidative Stress

doi: 10.7759/cureus.80486

Figure Lengend Snippet: a) Protease-activated receptor 1 (PAR1) and the number of rears, b) Endothelin 1 (ET1) and the number of rears, c) PAR1 and the average displacement distance of each of the right and the left forepaw, d) ET1 and the average displacement distance of each of the right and the left forepaw, e) PAR1 and each of time to pick pasta (TPP) and time to finish eating (TTF), f) ET1 and each of TPP and TTF, g) PAR1 and number of times of adjustments of forepaws (NTAF), h) ET1 and NTAF. PAR1: protease-activated receptor 1; ET1: endothelin 1; TPP: time to pick up pasta; TTF: time to finish eating; NTAF: number of times of adjustment of forepaws. Spearman rho. Significant when Ρ < 0.05.

Article Snippet: DA and ET1 ELISA kits were purchased from Cusabio (USA).

Techniques:

a) Protease-activated receptor 1 (PAR1) and dopamine (DA), b) Endothelin 1 (ET1) and DA, c) PAR1 and dopamine receptor type 2 (D2). PAR1: protease-activated receptor 1; ET1: endothelin 1; DA: dopamine; D2: dopamine receptor type 2 Spearman rho. Significant when Ρ < 0.05.

Journal: Cureus

Article Title: Dabigatran Combined With Benztropine Ameliorates Cobalt Chloride-Induced Parkinsonism in Rats, Restores Protease-Activated Receptor 1 (PAR1), and Mitigates Oxidative Stress

doi: 10.7759/cureus.80486

Figure Lengend Snippet: a) Protease-activated receptor 1 (PAR1) and dopamine (DA), b) Endothelin 1 (ET1) and DA, c) PAR1 and dopamine receptor type 2 (D2). PAR1: protease-activated receptor 1; ET1: endothelin 1; DA: dopamine; D2: dopamine receptor type 2 Spearman rho. Significant when Ρ < 0.05.

Article Snippet: DA and ET1 ELISA kits were purchased from Cusabio (USA).

Techniques:

a) Protease-activated receptor 1 (PAR1) and adenosine receptor type 1 (A1), b) Endothelin 1 (ET1) and A1, c) PAR1 and adenosine receptor type 2A (A2A), d) ET1 and A2A, e) PAR1 and A1/A2A, f) ET1 and A1/A2A. PAR1: protease-activated receptor 1; ET1: endothelin 1; A1: adenosine receptor type 1; A2A: adenosine receptor type 2A; A1/A2A: ratio of adenosine receptor type 1 and adenosine receptor type 2. Spearman rho. Significant when Ρ < 0.05.

Journal: Cureus

Article Title: Dabigatran Combined With Benztropine Ameliorates Cobalt Chloride-Induced Parkinsonism in Rats, Restores Protease-Activated Receptor 1 (PAR1), and Mitigates Oxidative Stress

doi: 10.7759/cureus.80486

Figure Lengend Snippet: a) Protease-activated receptor 1 (PAR1) and adenosine receptor type 1 (A1), b) Endothelin 1 (ET1) and A1, c) PAR1 and adenosine receptor type 2A (A2A), d) ET1 and A2A, e) PAR1 and A1/A2A, f) ET1 and A1/A2A. PAR1: protease-activated receptor 1; ET1: endothelin 1; A1: adenosine receptor type 1; A2A: adenosine receptor type 2A; A1/A2A: ratio of adenosine receptor type 1 and adenosine receptor type 2. Spearman rho. Significant when Ρ < 0.05.

Article Snippet: DA and ET1 ELISA kits were purchased from Cusabio (USA).

Techniques:

a) Malondialdehyde (MDA) and each of protease-activated receptor 1 (PAR1) and endothelin 1 (ET1), b) Glutathione (GSH) and each of PAR1 and ET1, c) MDA/GSH and each of PAR1 and ET1. MDA: malondialdehyde; GSH: reduced glutathione; MDA/GSH: ratio of malondialdehyde and reduced glutathione; PAR1: protease-activated receptor 1; ET1: endothelin 1. Spearman rho. Significant when Ρ < 0.05.

Journal: Cureus

Article Title: Dabigatran Combined With Benztropine Ameliorates Cobalt Chloride-Induced Parkinsonism in Rats, Restores Protease-Activated Receptor 1 (PAR1), and Mitigates Oxidative Stress

doi: 10.7759/cureus.80486

Figure Lengend Snippet: a) Malondialdehyde (MDA) and each of protease-activated receptor 1 (PAR1) and endothelin 1 (ET1), b) Glutathione (GSH) and each of PAR1 and ET1, c) MDA/GSH and each of PAR1 and ET1. MDA: malondialdehyde; GSH: reduced glutathione; MDA/GSH: ratio of malondialdehyde and reduced glutathione; PAR1: protease-activated receptor 1; ET1: endothelin 1. Spearman rho. Significant when Ρ < 0.05.

Article Snippet: DA and ET1 ELISA kits were purchased from Cusabio (USA).

Techniques: